A rural agricultural-sustainable energy community model and its application to Felton Valley, Australia

Energy and food security require a delicate balance which should not threaten or undermine community prosperity. Where it is proposed to derive energy from conventional fossil fuel resources (such as coal, shale oil, natural gas, coal seam gas) located in established rural areas, and particularly where these areas are used for productive agricultural purposes, there are often both intense community concern as well as broader questions regarding the relative social, economic and environmental costs and benefits of different land uses and, increasingly, different energy sources. The advent of mainstream renewable energy technologies means that alternative energy options may provide a viable alternative, allowing energy demand to be met without compromising existing land uses. We demonstrate how such a Sustainable Energy Rural Model can be designed to achieve a balance between the competing social goals of energy supply, agricultural production, environmental integrity and social well-being, and apply it to the Felton Valley, a highly productive and resilient farming community in eastern Australia. Research into available wind and solar resources found that Felton Valley has a number of attributes that indicate its suitability for the development of an integrated renewable energy precinct which would complement, rather than displace, existing agricultural enterprises. Modelling results suggest a potential combined annual renewable energy output from integrated wind and solar resources of 1,287 GWh/yr from peak installed capacity of 713 MW, sufficient to supply the electrical energy needs of about 160,000 homes, in combination with total biomass food production of 31,000 tonnes per annum or 146 GWh/yr of human food energy. The portfolio of renewable energy options will not only provide energy source diversity but also ensures long-term food security and regional stability. The Felton Valley model provides an example of community-led energy transformation and has potential as a pilot project for the development of smart distributed grids that would negate the need for further expansion of coal mining and coal fired power stations

Arresting woodland bird decline in Australian agricultural landscapes: potential application of the European agri-environment model

This paper considered the applicability of the European model of land stewardship payments, in particular its support for biodiversity conservation in agricultural landscapes, to an Australian context. More broadly, the research approach described in the paper may also be applied to assessing the suitability of overseas stewardship schemes to the provision of any ecoservice in Australia, such as carbon sequestration and floodwater regulation

Modelling drought impacts on coffee production in Viet Nam: a system dynamics approach

Viet Nam is the world’s largest producer of Robusta coffee, accounting for more than 40% of global Robusta output. Coffee production contributes to about 10% of agricultural export turnover in the country and supports the livelihoods of approximately half a million smallholder farmers. However, coffee cultivation faces numerous challenges, particularly drought and water shortages driven by changing climate conditions and unsustainable agricultural practices. Using a system dynamics approach, our study aims to assess the major impacts of drought affecting sustainable coffee production in Dak Lak Province, a key coffee growing region responsible for more than 30% of Viet Nam’s coffee output. A dynamic hypothesis (causal loop diagram) was formulated based on literature review and qualitative data from interviews with 60 coffee farmers and experts to capture the interrelationships and feedbacks among factors relating to drought impacts on coffee production. Mapping these relationships to produce the causal loop diagram indicates that the consequences of drought on coffee cultivation are an outcome of complex interactions between the climate system and human systems, specifically population growth, deforestation and agricultural development. Key factors driving drought impacts on coffee production are declining rainfall in the dry season, increasing coffee expansion and over-irrigation, which interact with other factors, such as rising temperature and evapotranspiration, through reinforcing and balancing feedback loops. The impact of drought on coffee yield and coffee quality mainly depends on drought severity and supplemental ground and surface water availability. Our analysis highlights several systems archetypes, including ‘tragedy of the commons’ and ‘limits to growth’, associated with overuse of regional common resources, triggered by uncontrollable agricultural expansion and water exploitation, particularly of groundwater for irrigation. The unintentional outcomes of a number of management decisions or policies (indicated through the ‘fixes that fail’ systems archetype)—such as the planned migration program which has led to population growth and deforestation, contributing to declining water availability—are also analysed. The monoculture cropping system of Robusta coffee also has undesirable consequences, including increasing vulnerability of the coffee system to changing climate and market risks such as price volatility. A suite of management strategies is proposed including awareness raising and promotion of technologies and policy measures on efficient water use for irrigation, sustainable planning for coffee development, livelihood diversification, agroforestry either through intercropping or shading, and forest protection, reforestation and afforestation. An initial simulation model based on these results is in progress for robust quantification of drought impacts and for the design and testing of various policy interventions for sustainable coffee production

Agricultural climate change mitigation : Carbon calculators as a guide for decision making

This is an Accepted Manuscript of an article published by Taylor & Francis Group in International Journal of Agricultural Sustainability on 9 November 2017, available online: https://doi.org/10.1080/14735903.2017.1398628. Under embargo. Embargo end date: 9 November 2018.The dairy industry is receiving considerable attention in relation to both its significant greenhouse gas (GHG) emissions, and it’s potential for reducing those emissions, contributing towards meeting national targets and driving the industry towards sustainable intensification. However, the extent to which improvements can be made is dependent on the decision making processes of individual producers, so there has been a proliferation of carbon accounting tools seeking to influence those processes. This paper evaluates the suitability of such tools for driving environmental change by influencing on-farm management decisions. Seven tools suitable for the European dairy industry were identified, their characteristics evaluated, and used to process data relating to six scenario farms, emulating process undertaken in real farm management situations. As a result of the range of approaches taken by the tools, there was limited agreement between them as to GHG emissions magnitude, and no consistent pattern as to which tools resulted in the highest/lowest results. Despite this it is argued, that as there was agreement as to the farm activities responsible for the greatest emissions, the more complex tools were still capable of performing a ‘decision support’ role, and guiding management decisions, whilst others could merely focus attention on key issues.Peer reviewe

Virtual discussions to support climate risk decision making on farms

Climate variability represents a significant risk to farming enterprises. Effective extension of climate information may improve climate risk decision making and adaptive management responses to climate variability on farms. This paper briefly reviews current agricultural extension approaches and reports stakeholder responses to new web-based virtual world ‘discussion-support’ tools developed for the Australian sugar cane farming industry. These tools incorporate current climate science and sugar industry better management practices, while leveraging the social-learning aspects of farming, to provide a stimulus for discussion and climate risk decision making. Responses suggest that such virtual world tools may provide effective support for climate risk decision making on Australian sugar cane farms. Increasing capacity to deliver such tools online also suggests potential to engage large numbers of farmers globally

Can digital discussion support tools provide cost-effective options for agricultural extension services?

Agricultural extension that delivers timely, targeted, and cost-effective support to farmers will help ensure the sustainability and adaptive capacity of agriculture, enhancing both food security and environmental security. Leveraging advances in agriclimate science and adult education, innovative digital technologies offer significant new opportunities to engage with farmers and to support decision making. In this study, animated video clips (machinimas), developed using the Second LifeTM virtual world gaming platform, model conversations around climate risk and critical on-farm decisions in the Australian sugarcane farming industry. Early evaluation indicates that this is an engaging format that promotes discussion by leveraging farmers’ natural modes of information gathering and social learning. Comparison with conventional extension practices indicates that these discussion support tools may be a cost effective addition to existing approaches. The format’s flexibility means machinimas are readily updated with new information and customized to meet the needs of different farmer groups. Rapid growth in digital access globally and the scalability of such approaches promise greater equity of access to high-value information, critical to better risk management decision making, at minimal cost, for millions of farmers

PARP inhibition utilized in combination therapy with Olaparib-Temozolomide to achieve disease stabilization in a rare case of BRCA1-mutant, metastatic myxopapillary ependymoma.

Myxopapillary ependymoma (MPE) is a primary tumor of the central nervous system (CNS), characteristically an indolent malignancy involving the spinal conus medullaris, Filum terminale or cauda equina. We present a rare case of MPE, recurrent in the pelvic soft tissue with eventual pleural and intra-pulmonary metastasis. Refractory to repeated gross resection, adjuvant radiotherapy, platinum-based chemotherapy and temozolomide exploitation of mutant somatic BRCA1 status with the addition of a poly (ADP-ribose); polymerase inhibitor (PARPi) in a novel combination regimen with olaparib-temozolomide (OT) has achieved stable radiological disease after 10 cycles

The solar chromosphere at high resolution with IBIS. I. New insights from the Ca II 854.2 nm line

(Abridged) Aims: In this paper, we seek to establish the suitability of imaging spectroscopy performed in the Ca II 854.2 nm line as a means to investigate the solar chromosphere at high resolution. Methods: We utilize monochromatic images obtained with the Interferometric BIdimensional Spectrometer (IBIS) at multiple wavelengths within the Ca II 854.2 nm line and over several quiet areas. We analyze both the morphological properties derived from narrow-band monochromatic images and the average spectral properties of distinct solar features such as network points, internetwork areas and fibrils. Results: The spectral properties derived over quiet-Sun targets are in full agreement with earlier results obtained with fixed-slit spectrographic observations, highlighting the reliability of the spectral information obtained with IBIS. Furthermore, the very narrowband IBIS imaging reveals with much clarity the dual nature of the Ca II 854.2 nm line: its outer wings gradually sample the solar photosphere, while the core is a purely chromospheric indicator. The latter displays a wealth of fine structures including bright points, akin to the Ca II H2V and K2V grains, as well as fibrils originating from even the smallest magnetic elements. The fibrils occupy a large fraction of the observed field of view even in the quiet regions, and clearly outline atmospheric volumes with different dynamical properties, strongly dependent on the local magnetic topology. This highlights the fact that 1-D models stratified along the vertical direction can provide only a very limited representation of the actual chromospheric physics.Comment: 13 pages, 8 figures. Accepted in A&A. Revised version after referee's comments. New Fig. 1 and 7. Higher quality figures in http://www.arcetri.astro.it/~gcauzzi/papers/ibis.caii.pd

Understanding the dynamics of Toll-like Receptor 5 response to flagellin and its regulation by estradiol

© 2017 The Author(s). Toll-like receptors (TLRs) are major players of the innate immune system. Once activated, they trigger a signalling cascade that leads to NF-ΰ B translocation from the cytoplasm to the nucleus. Single cell analysis shows that NF-ΰ B signalling dynamics are a critical determinant of transcriptional regulation. Moreover, the outcome of innate immune response is also affected by the cross-talk between TLRs and estrogen signalling. Here, we characterized the dynamics of TLR5 signalling, responsible for the recognition of flagellated bacteria, and those changes induced by estradiol in its signalling at the single cell level. TLR5 activation in MCF7 cells induced a single and sustained NF-k B translocation into the nucleus that resulted in high NF-k B transcription activity. The overall magnitude of NF-k B transcription activity was not influenced by the duration of the stimulus. No significant changes are observed in the dynamics of NF-k B translocation to the nucleus when MCF7 cells are incubated with estradiol. However, estradiol significantly decreased NF-k B transcriptional activity while increasing TLR5-mediated AP-1 transcription. The effect of estradiol on transcriptional activity was dependent on the estrogen receptor activated. This fine tuning seems to occur mainly in the nucleus at the transcription level rather than affecting the translocation of the NF-k B transcription factor

The conserved C-terminus of the PcrA/UvrD helicase interacts directly with RNA polymerase

Copyright: © 2013 Gwynn et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This work was supported by a Wellcome Trust project grant to MD (Reference: 077368), an ERC starting grant to MD (Acronym: SM-DNA-REPAIR) and a BBSRC project grant to PM, NS and MD (Reference: BB/I003142/1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD